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Лекарственный препарат Алкеран

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                    [DISCOUNT_DIFF_PERCENT] => 0
                )

            [CATALOG_QUANTITY] => 100
            [MAX_QUANTITY] => 100
            [CATALOG_MEASURE_RATIO] => 1
            [MEASURE] => 
            [CAN_BUY] => 1
            [CAN_BUY_ZERO] => 
        )

    [28453] => Array
        (
            [ID] => 28453
            [TIMESTAMP_X] => 14.10.2019 19:12:39
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            [MODIFIED_BY] => 1
            [DATE_CREATE] => 14.10.2019 19:12:39
            [DATE_CREATE_UNIX] => 1571055159
            [CREATED_BY] => 1
            [IBLOCK_ID] => 26
            [IBLOCK_SECTION_ID] => 
            [ACTIVE] => Y
            [ACTIVE_FROM] => 
            [ACTIVE_TO] => 
            [DATE_ACTIVE_FROM] => 
            [DATE_ACTIVE_TO] => 
            [SORT] => 500
            [NAME] => Алкеран пор. для инъекций 50 мг №1
            [PREVIEW_PICTURE] => Array
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            [PREVIEW_TEXT] => 
            [PREVIEW_TEXT_TYPE] => text
            [DETAIL_PICTURE] => Array
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                    [SRC] => /upload/iblock/a6a/a6a93ef6dc5556ec8b16315d2a33bb69.jpg
                )

            [DETAIL_TEXT] => 
            [DETAIL_TEXT_TYPE] => text
            [SEARCHABLE_CONTENT] => АЛКЕРАН ПОР. ДЛЯ ИНЪЕКЦИЙ 50 МГ №1
            [WF_STATUS_ID] => 1
            [WF_PARENT_ELEMENT_ID] => 
            [WF_LAST_HISTORY_ID] => 
            [WF_NEW] => 
            [LOCK_STATUS] => green
            [WF_LOCKED_BY] => 
            [WF_DATE_LOCK] => 
            [WF_COMMENTS] => 
            [IN_SECTIONS] => N
            [SHOW_COUNTER] => 
            [SHOW_COUNTER_START] => 
            [SHOW_COUNTER_START_X] => 
            [CODE] => 
            [TAGS] => 
            [XML_ID] => 28453
            [EXTERNAL_ID] => 28453
            [TMP_ID] => 9cd628030b2de182c9b624124a4db828
            [USER_NAME] => (Midnik) Ivan VIS
            [LOCKED_USER_NAME] => 
            [CREATED_USER_NAME] => (Midnik) Ivan VIS
            [LANG_DIR] => /
            [LID] => s1
            [IBLOCK_TYPE_ID] => offers
            [IBLOCK_CODE] => offers
            [IBLOCK_NAME] => Торговые предложения
            [IBLOCK_EXTERNAL_ID] => 
            [DETAIL_PAGE_URL] => /catalog/lekarstvennye-preparaty/protivoopukholevye/alkeran/
            [LIST_PAGE_URL] => /catalog/
            [CANONICAL_PAGE_URL] => 
            [CREATED_DATE] => 2019.10.14
            [BP_PUBLISHED] => Y
            [PROPERTIES] => Array
                (
                    [STARTSHOP_QUANTITY] => Array
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                            [TIMESTAMP_X] => 2019-10-14 16:10:42
                            [IBLOCK_ID] => 26
                            [NAME] => Количество
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                            [SORT] => 1
                            [CODE] => STARTSHOP_QUANTITY
                            [DEFAULT_VALUE] => 0
                            [PROPERTY_TYPE] => N
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => Y
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
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                            [VALUE] => 100
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
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                            [~NAME] => Количество
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                            [VALUE_ENUM_ID] => 
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                    [STARTSHOP_QUANTITY_RATIO] => Array
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                            [TIMESTAMP_X] => 2019-10-14 16:10:42
                            [IBLOCK_ID] => 26
                            [NAME] => Коэффициент количества
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                            [CODE] => STARTSHOP_QUANTITY_RATIO
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => Y
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
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                            [DESCRIPTION] => 
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                            [VALUE_XML_ID] => 
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                            [VALUE_ENUM_ID] => 
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                    [STARTSHOP_CURRENCY_1] => Array
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                            [TIMESTAMP_X] => 2019-10-14 16:10:42
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                            [SORT] => 3
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                            [DEFAULT_VALUE] => 0
                            [PROPERTY_TYPE] => L
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 191978
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                            [DESCRIPTION] => 
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                            [~DESCRIPTION] => 
                            [~NAME] => Валюта для "Базовая"
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                    [STARTSHOP_PRICE_1] => Array
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                            [TIMESTAMP_X] => 2019-10-14 16:10:42
                            [IBLOCK_ID] => 26
                            [NAME] => Базовая
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                            [SORT] => 4
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                            [DEFAULT_VALUE] => 0
                            [PROPERTY_TYPE] => N
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 191979
                            [VALUE] => 35300
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
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                            [~DESCRIPTION] => 
                            [~NAME] => Базовая
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                            [VALUE_ENUM_ID] => 
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                    [MORE_PHOTE] => Array
                        (
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                            [TIMESTAMP_X] => 2018-06-18 20:19:18
                            [IBLOCK_ID] => 26
                            [NAME] => Дополнительные изображения
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => MORE_PHOTE
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => F
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => Y
                            [XML_ID] => 
                            [FILE_TYPE] => jpg, gif, bmp, png, jpeg
                            [MULTIPLE_CNT] => 5
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => Дополнительные изображения
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
                        )

                    [COLOR] => Array
                        (
                            [ID] => 152
                            [TIMESTAMP_X] => 2018-06-19 16:45:41
                            [IBLOCK_ID] => 26
                            [NAME] => Цвет
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => COLOR
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => S
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
                            [MULTIPLE_CNT] => 5
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => directory
                            [USER_TYPE_SETTINGS] => Array
                                (
                                    [size] => 1
                                    [width] => 0
                                    [group] => N
                                    [multiple] => N
                                    [TABLE_NAME] => universe_colors
                                )

                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => Цвет
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
                        )

                    [SIZE] => Array
                        (
                            [ID] => 153
                            [TIMESTAMP_X] => 2018-06-18 20:19:18
                            [IBLOCK_ID] => 26
                            [NAME] => Размер
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => SIZE
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => L
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
                            [MULTIPLE_CNT] => 5
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [VALUE_ENUM_ID] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => Размер
                            [~DEFAULT_VALUE] => 
                        )

                    [STARTSHOP_LINK] => Array
                        (
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                            [TIMESTAMP_X] => 2018-08-28 17:25:02
                            [IBLOCK_ID] => 26
                            [NAME] => Свойство привязки
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => STARTSHOP_LINK
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => E
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
                            [MULTIPLE_CNT] => 5
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 191975
                            [VALUE] => 5100
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
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                            [~DESCRIPTION] => 
                            [~NAME] => Свойство привязки
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
                        )

                    [NAME] => Array
                        (
                            [ID] => 159
                            [TIMESTAMP_X] => 2018-06-26 16:05:05
                            [IBLOCK_ID] => 26
                            [NAME] => Название 2
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => NAME
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => L
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
                            [MULTIPLE_CNT] => 5
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [VALUE_ENUM_ID] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => Название 2
                            [~DEFAULT_VALUE] => 
                        )

                    [URL] => Array
                        (
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                            [TIMESTAMP_X] => 2019-01-30 19:09:51
                            [IBLOCK_ID] => 26
                            [NAME] => URL
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => URL
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => S
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
                            [MULTIPLE_CNT] => 5
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => URL
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
                        )

                    [DATA] => Array
                        (
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                            [TIMESTAMP_X] => 2019-01-30 19:09:51
                            [IBLOCK_ID] => 26
                            [NAME] => Дата
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                            [SORT] => 500
                            [CODE] => DATA
                            [DEFAULT_VALUE] => 
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
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                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => Дата
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
                        )

                    [PHARMACIES] => Array
                        (
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                            [TIMESTAMP_X] => 2019-08-12 14:53:52
                            [IBLOCK_ID] => 26
                            [NAME] => Аптеки
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => PHARMACIES
                            [DEFAULT_VALUE] => 
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                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => Y
                            [XML_ID] => 
                            [FILE_TYPE] => 
                            [MULTIPLE_CNT] => 3
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 27
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => Array
                                (
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                                )

                            [VALUE] => Array
                                (
                                    [0] => 28183
                                )

                            [DESCRIPTION] => Array
                                (
                                    [0] => 
                                )

                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => Array
                                (
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                            [~DESCRIPTION] => Array
                                (
                                    [0] => 
                                )

                            [~NAME] => Аптеки
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
                        )

                    [PARTNER_URL] => Array
                        (
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                            [TIMESTAMP_X] => 2019-10-14 16:10:42
                            [IBLOCK_ID] => 26
                            [NAME] => Партнерская ссылка
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => PARTNER_URL
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => S
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
                            [MULTIPLE_CNT] => 5
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 191981
                            [VALUE] => https://ad.admitad.com/g/ueue9fvy7ua0343e5b43283e9831b7/?i=5&f_id=17691&ulp=https%3A%2F%2Fapteka-med.com%2Fcatalog%2Fprotivoopuxolevye%2Falkeran-50mg-1amp%2F
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => https://ad.admitad.com/g/ueue9fvy7ua0343e5b43283e9831b7/?i=5&f_id=17691&ulp=https%3A%2F%2Fapteka-med.com%2Fcatalog%2Fprotivoopuxolevye%2Falkeran-50mg-1amp%2F
                            [~DESCRIPTION] => 
                            [~NAME] => Партнерская ссылка
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
                        )

                    [ID_PARTNER_LEK] => Array
                        (
                            [ID] => 172
                            [TIMESTAMP_X] => 2019-10-14 19:00:11
                            [IBLOCK_ID] => 26
                            [NAME] => ID лекарства в партнерке
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => ID_PARTNER_LEK
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => S
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
                            [MULTIPLE_CNT] => 5
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 191982
                            [VALUE] => 7771647
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => 7771647
                            [~DESCRIPTION] => 
                            [~NAME] => ID лекарства в партнерке
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
                        )

                )

            [STARTSHOP] => Array
                (
                    [PRICES] => Array
                        (
                            [LIST] => Array
                                (
                                    [BASE] => Array
                                        (
                                            [VALUE] => 35300
                                            [CURRENCY] => RUB
                                            [PRINT_VALUE] => 35 300 руб.
                                            [TYPE] => BASE
                                        )

                                )

                            [MINIMAL] => Array
                                (
                                    [VALUE] => 35300
                                    [CURRENCY] => RUB
                                    [PRINT_VALUE] => 35 300 руб.
                                    [TYPE] => BASE
                                )

                        )

                    [BASKET] => Array
                        (
                            [INSIDE] => 
                            [QUANTITY] => 0
                            [PRICE] => Array
                                (
                                    [VALUE] => 35300
                                    [CURRENCY] => RUB
                                    [PRINT_VALUE] => 35 300 руб.
                                    [TYPE] => BASE
                                )

                        )

                    [QUANTITY] => Array
                        (
                            [USE] => 1
                            [RATIO] => 1
                            [VALUE] => 100
                        )

                    [AVAILABLE] => 1
                    [OFFER] => Array
                        (
                            [OFFER] => 1
                            [PROPERTIES] => Array
                                (
                                )

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                        )

                )

            [PRICE] => Array
                (
                    [VALUE] => 35300
                    [CURRENCY] => RUB
                    [PRINT_VALUE] => 35 300 руб.
                    [TYPE] => BASE
                    [DISCOUNT_VALUE] => 35 300 руб.
                    [PRINT_DISCOUNT_VALUE] => 35 300 руб.
                    [DISCOUNT_DIFF] => 0
                    [DISCOUNT_DIFF_PERCENT] => 0
                )

            [CATALOG_QUANTITY] => 100
            [MAX_QUANTITY] => 100
            [CATALOG_MEASURE_RATIO] => 1
            [MEASURE] => 
            [CAN_BUY] => 1
            [CAN_BUY_ZERO] => 
        )

)

Инструкция по применению Алкеран

Производитель

**** Глаксо Вэллком ГмбХ & Ко ГлаксоСмитКляйн ГмбХ Ко.КГ/ Хойманн Фарма ГмбХ ГлаксоСмитКляйн ГмбХ и Ко. КГ/Хойманн Фарма ГмбХ ГлаксоСмитКляйн Фармасьютикалз С.А. Экселла ГмБх

Страна происхождения

Германия Испания Италия

Группа товаров

Противоопухолевые препараты

Противоопухолевый препарат

Формы выпуска

  • 25 - флаконы темного стекла (1) - пачки картонные.

Описание лекарственной формы

  • Таблетки, покрытые пленочной оболочкой белого или почти белого цвета, круглые, двояковыпуклые, с клеймом "GX EH3" на одной стороне и "А" - на другой; ядро таблетки белого или почти белого цвета

Фармакологическое действие

Противоопухолевый препарат алкилирующего действия. Является бифункциональным соединением. Процесс алкилирования состоит в ковалентном связывании образующихся из двух бис-2-хлорэтильных групп углеродных промежуточных соединений с 7-азотом гуанина в ДНК и перекрестном связывании двух спиралей ДНК, что приводит к нарушению репликации клеток

Особые условия

Алкеран является цитотоксическим средством и предназначен для использования только под контролем врачей, имеющих опыт применения подобных препаратов. Учитывая известный риск, возникающий при лечении препаратом, и необходимость вспомогательной терапии, применение раствора Алкерана в высоких дозах должно проводиться в специализированных центрах, имеющих соответствующие условия, и только опытными специалистами. У пациентов, получающих высокие дозы Алкерана, необходимо решить вопрос о профилактическом назначении антибактериальных средств, использовании при необходимости препаратов компонентов крови и поддержании обильного диуреза непосредственно после введения Алкерана (путем применения гидратации и форсированного диуреза). Перед введением высоких доз Алкерана следует убедиться в адекватности общего состояния пациента и функции внутренних органов. При использовании Алкерана следует выполнять рекомендации по применению цитотоксических препаратов. Раствор Алкерана в случае попадания его в окружающие сосуд ткани может приводить к локальному повреждению тканей. Алкеран следует применять с осторожностью у пациентов, недавно прошедших курс лучевой терапии или химиотерапии, в связи с возможностью усиления токсического действия на костный мозг. У пациентов с почечной недостаточностью возможно подавление функции кроветворения на фоне уремии. У пациентов с миеломой и нарушением функции почек на ранних этапах лечения мелфаланом наблюдалось временное выраженное повышение уровня мочевины крови. Мелфалан угнетает функцию яичников у женщин в пременопаузе, приводя к аменорее у значительного количества пациенток. По данным исследований у животных, мелфалан может оказывать неблагоприятное действие на сперматогенез. Поэтому допускается, что мелфалан может вызывать временную или стойкую стерильность у пациентов мужского пола. У пациентов, которым проводилось лечение мелфаланом, были отмечены хромосомные аберрации. Мелфалан, как и другие алкилирующие средства, может оказывать лейкозогенное действие у человека. Имеются сообщения о развитии острого лейкоза после длительного лечения мелфаланом таких заболеваний как амилоидоз, злокачественная меланома, множественная миелома, макроглобулинемия, синдром холодовой гемагглютинации и рак яичников. Было показано, что у пациентов с раком яичников применение алкилирующих средств, включая мелфалан, значительно повышало заболеваемость острым лейкозом по сравнению с пациентами, которым не проводилось лечение алкилирующими препаратами. При решении вопроса о назначении мелфалана следует сопоставить риск проявления лейкозогенного действия и потенциальный терапевтический эффект препарата. Контроль лабораторных показателей Необходимо регулярно контролировать гематологические показатели во избежание возможного развития выраженной миелосупрессии и риска необратимой аплазии костного мозга. Количество клеток крови может продолжать снижаться и после отмены препарата, поэтому при первых признаках чрезмерного снижения количества лейкоци

Состав

  • мелфалан2 мг Вспомогательные вещества: целлюлоза микрокристаллическая, кросповидон, кремния диоксид коллоидный, магния стеарат. Состав оболочки: Опадрай белый YS-1-18097-A (гипромеллоза, титана диоксид, макрогол).

Алкеран показания к применению

  • Показан при: — множественной миеломе; — распространенной аденокарциноме яичника. Может применяться при: — карциноме молочной железы; — истинной полицитемии.

Алкеран противопоказания

  • повышенная чувствительность к мелфалану

Алкеран дозировка

  • 2 мг 2мг 50мг

Алкеран побочные действия

  • Со стороны системы кроветворения и лимфатической системы: очень часто - угнетение костномозгового кроветворения с развитием лейкопении и тромбоцитопении; редко – гемолитическая анемия. Со стороны иммунной системы: редко – аллергические реакции (крапивница, отек, кожная сыпь, зуд и анафилактический шок при первом и последующих введениях отмечались нечасто, главным образом при в/в терапии Алкераном). Есть сообщения о редких случаях остановки сердца при аллергических реакциях на Алкеран. Со стороны дыхательной системы: редко - интерстициальная пневмония и легочный фиброз (в т.ч. с летальным исходом). Со стороны пищеварительной системы: очень часто - тошнота, рвота и диарея; при использовании высокодозного режима – стоматит; редко - поражения печени, начиная от изменения активности функциональных печеночных проб до клинически манифестного гепатита и желтухи, вено-окклюзионная болезнь после высокодозной терапии, стоматит при применении стандартных доз. При парентеральном введении: диарея, тошнота, рвота являются дозолимитирующими факторами токсичности у пациентов, получающих в/в высокодозную терапию Алкераном вместе с трансплантацией гемопоэтических стволовых клеток. Предшествующая терапия циклофосфамидом, по-видимому, уменьшает выраженность симптомов со стороны ЖКТ, обусловленных высокой дозой Алкерана. При приеме внутрь: по имеющимся данным, до 30% больных, получающих мелфалан внутрь в стандартных дозах, отмечают побочные эффекты со стороны пищеварительной системы

Лекарственное взаимодействие

Увеличивает вероятность нарушения функции почек у пациентов с трансплантацией костного мозга, получающих циклоспорин для профилактики реакции \"трансплантат против хозяина\". Необходимо избегать одновременного применения с налидиксовой кислотой и циклоспорином. У детей несовместим (в/в) с налидиксовой кислотой - возможен летальный исход как следствие геморрагического энтероколита

Условия хранения

  • Хранить в холоде (t 2 - 5)
  • беречь от детей
Отзывы Алкеран
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