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Лекарственный препарат Метромикон-Нео

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            [CATALOG_QUANTITY] => 100
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            [CATALOG_MEASURE_RATIO] => 1
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            [CAN_BUY_ZERO] => 
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            [ACTIVE_TO] => 
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            [DATE_ACTIVE_TO] => 
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            [PREVIEW_TEXT] => 
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            [DETAIL_TEXT] => 
            [DETAIL_TEXT_TYPE] => text
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            [WF_PARENT_ELEMENT_ID] => 
            [WF_LAST_HISTORY_ID] => 
            [WF_NEW] => 
            [LOCK_STATUS] => green
            [WF_LOCKED_BY] => 
            [WF_DATE_LOCK] => 
            [WF_COMMENTS] => 
            [IN_SECTIONS] => N
            [SHOW_COUNTER] => 
            [SHOW_COUNTER_START] => 
            [SHOW_COUNTER_START_X] => 
            [CODE] => 
            [TAGS] => 
            [XML_ID] => 32106
            [EXTERNAL_ID] => 32106
            [TMP_ID] => 9cd628030b2de182c9b624124a4db828
            [USER_NAME] => (Midnik) Ivan VIS
            [LOCKED_USER_NAME] => 
            [CREATED_USER_NAME] => (Midnik) Ivan VIS
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            [LID] => s1
            [IBLOCK_TYPE_ID] => offers
            [IBLOCK_CODE] => offers
            [IBLOCK_NAME] => Торговые предложения
            [IBLOCK_EXTERNAL_ID] => 
            [DETAIL_PAGE_URL] => /catalog/lekarstvennye-preparaty/protivogribkovye/metromikon-neo/
            [LIST_PAGE_URL] => /catalog/
            [CANONICAL_PAGE_URL] => 
            [CREATED_DATE] => 2019.10.14
            [BP_PUBLISHED] => Y
            [PROPERTIES] => Array
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                    [STARTSHOP_QUANTITY_RATIO] => Array
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                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
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                            [XML_ID] => 
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                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
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                            [VALUE_ENUM] => 
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                            [IBLOCK_ID] => 26
                            [NAME] => Дополнительные изображения
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                            [SORT] => 500
                            [CODE] => MORE_PHOTE
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                            [LIST_TYPE] => L
                            [MULTIPLE] => Y
                            [XML_ID] => 
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                            [TMP_ID] => 
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                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
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                            [~DESCRIPTION] => 
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                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
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                    [COLOR] => Array
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                            [TIMESTAMP_X] => 2018-06-19 16:45:41
                            [IBLOCK_ID] => 26
                            [NAME] => Цвет
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                            [SORT] => 500
                            [CODE] => COLOR
                            [DEFAULT_VALUE] => 
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => directory
                            [USER_TYPE_SETTINGS] => Array
                                (
                                    [size] => 1
                                    [width] => 0
                                    [group] => N
                                    [multiple] => N
                                    [TABLE_NAME] => universe_colors
                                )

                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
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                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => Цвет
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
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                    [SIZE] => Array
                        (
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                            [TIMESTAMP_X] => 2018-06-18 20:19:18
                            [IBLOCK_ID] => 26
                            [NAME] => Размер
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                            [SORT] => 500
                            [CODE] => SIZE
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
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                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
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                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [VALUE_ENUM_ID] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => Размер
                            [~DEFAULT_VALUE] => 
                        )

                    [STARTSHOP_LINK] => Array
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                            [TIMESTAMP_X] => 2018-08-28 17:25:02
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                            [NAME] => Свойство привязки
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                            [SORT] => 500
                            [CODE] => STARTSHOP_LINK
                            [DEFAULT_VALUE] => 
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 223199
                            [VALUE] => 10895
                            [DESCRIPTION] => 
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                            [~DESCRIPTION] => 
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                    [NAME] => Array
                        (
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                            [TIMESTAMP_X] => 2018-06-26 16:05:05
                            [IBLOCK_ID] => 26
                            [NAME] => Название 2
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                            [SORT] => 500
                            [CODE] => NAME
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => L
                            [ROW_COUNT] => 1
                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
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                    [URL] => Array
                        (
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                            [NAME] => URL
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                            [SORT] => 500
                            [CODE] => URL
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
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                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
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                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
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                            [VALUE_SORT] => 
                            [~VALUE] => 
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                            [NAME] => Дата
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                            [XML_ID] => 
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                            [TMP_ID] => 
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                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
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                            [TIMESTAMP_X] => 2019-08-12 14:53:52
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                            [CODE] => PHARMACIES
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                            [LIST_TYPE] => L
                            [MULTIPLE] => Y
                            [XML_ID] => 
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                            [TMP_ID] => 
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                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => Array
                                (
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                            [VALUE] => Array
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                            [DESCRIPTION] => Array
                                (
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                            [VALUE_ENUM] => 
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                                (
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                            [~DESCRIPTION] => Array
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                            [~NAME] => Аптеки
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                    [PARTNER_URL] => Array
                        (
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                            [TIMESTAMP_X] => 2019-10-14 16:10:42
                            [IBLOCK_ID] => 26
                            [NAME] => Партнерская ссылка
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                            [SORT] => 500
                            [CODE] => PARTNER_URL
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
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                            [VALUE] => https://ad.admitad.com/g/n6u4ca5tpwa0343e5b438de46d4bd6/?i=5&f_id=16838&ulp=https%3A%2F%2Fdialog.ru%2Fproduct%2Fmetromikon_neo_suppozitorii_vaginalnye_500mg_100mg_14%2F
                            [DESCRIPTION] => 
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                            [~VALUE] => https://ad.admitad.com/g/n6u4ca5tpwa0343e5b438de46d4bd6/?i=5&f_id=16838&ulp=https%3A%2F%2Fdialog.ru%2Fproduct%2Fmetromikon_neo_suppozitorii_vaginalnye_500mg_100mg_14%2F
                            [~DESCRIPTION] => 
                            [~NAME] => Партнерская ссылка
                            [~DEFAULT_VALUE] => 
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                    [ID_PARTNER_LEK] => Array
                        (
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                            [TIMESTAMP_X] => 2019-10-14 19:00:11
                            [IBLOCK_ID] => 26
                            [NAME] => ID лекарства в партнерке
                            [ACTIVE] => Y
                            [SORT] => 500
                            [CODE] => ID_PARTNER_LEK
                            [DEFAULT_VALUE] => 
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
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                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
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                            [VALUE] => 666503
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => 666503
                            [~DESCRIPTION] => 
                            [~NAME] => ID лекарства в партнерке
                            [~DEFAULT_VALUE] => 
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                )

            [STARTSHOP] => Array
                (
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                                            [TYPE] => BASE
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                                )

                            [MINIMAL] => Array
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                                    [CURRENCY] => RUB
                                    [PRINT_VALUE] => 307 руб.
                                    [TYPE] => BASE
                                )

                        )

                    [BASKET] => Array
                        (
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                            [PRICE] => Array
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                                    [PRINT_VALUE] => 307 руб.
                                    [TYPE] => BASE
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                        )

                    [QUANTITY] => Array
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                        )

                    [AVAILABLE] => 1
                    [OFFER] => Array
                        (
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                            [PROPERTIES] => Array
                                (
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Рецептурный препарат Рецептурный препарат. Рецепт остается в аптеке

Инструкция по применению Метромикон-Нео

Производитель

Анжеро-Судженский ХФЗ,ООО Фармаприм ООО

Страна происхождения

Молдова, республика Россия

Группа товаров

Противогрибковые препараты

Противомикробное средство комбинированное (противомикробное и противопротозойное средство + противогрибковое средство)

Формы выпуска

  • суппозитории вагинальные 14 штук в уп

Описание лекарственной формы

  • Белые или белые с желтоватым оттенком суппозитории торпедообразной формы. На срезе допускается наличие воздушного стержня или воронкообразного углубления.

Фармакологическое действие

Метромикон-Нео – комбинированный препарат с противопротозойным, противогрибковым и антибактериальным действием. Содержит метронидазол и миконазол. Фармакодинамика. Метронидазол относится к 5-нитроимидазолам и является препаратом с бактерицидным типом действия, проявляющим тропность (способность взаимодействия) к дезоксирибонуклеиновой кислоте. Механизм действия заключается в биохимическом восстановлении 5-нитрогруппы метронидазола внутриклеточными транспортными протеинами анаэробных микроорганизмов и простейших. Восстановленная 5-нитрогруппа метронидазола взаимодействует с дезоксирибонуклеиновой кислотой клетки микроорганизмов, ингибируя синтез их нуклеиновых кислот, что ведет к гибели бактерий. Активен в отношении простейших: Trichomonas vaginalis, Entamoeba histolytica, а также облигатных анаэробных бактерий: грамотрицательных- Bacteroides spp. (в том числе Bacteroides fragilis, Bacteroides distasоnis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens), грамположительных - Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp., Mobiluncus spp. и факультативного анаэроба – Gardnerella vaginalis. К метронидазолу нечувствительны аэробные микроорганизмы, но в присутствии смешанной флоры (аэробы и анаэробы) метронидазол действует синергично с антибиотиками, эффективными против обычных аэробов. Миконазол является противогрибковым средством, производным азола. При интравагинальном применении активен в основном в отношении Candida albicans. Фунгицидный и фунгистатический эффект миконазола обусловлен ингибированием биосинтеза эргостерола оболочки и плазматических мембран грибов, изменением липидного состава и проницаемости клеточной стенки, вызывая гибель клетки гриба.

Фармакокинетика

По сравнению с приемом внутрь биодоступность метронидазола при интравагинальном введении составляет 20 %. Метронидазол метаболизируется в печени. Гидроксильные метаболиты активны. Период полувыведения метронидазола составляет 6 - 11 ч. Около 20 % дозы выводится в неизмененном виде с мочой. При интравагинальном введении миконазол всасывается незначительно и в плазме не определяется.

Особые условия

При применении препарата следует воздерживаться от половых контактов. С целью избежания повторного инфицирования необходимо одновременное лечение полового партнера. В случае трихомонадного вагинита целесообразно одновременное лечение полового партнера метронидазолом для приема внутрь. Во время лечения и, по крайней мере, в течение 24-48 ч после окончания курса лечения следует избегать приема этанола (возможна непереносимость этанола). Не рекомендуется одновременное применение препарата с контрацептивными диафрагмами и презервативами из каучука или латекса (возможно взаимодействие с основой суппозиториев). При сильном раздражении влагалища лечение препаратом следует прекратить. Суппозитории следует применять только интравагинально, их нельзя проглатывать или применять другим способом. В случае применения препарата совместно с метронидазолом для приема внутрь, особенно при повторном курсе, необходим контроль картины периферической крови (опасность лейкопении). Влияние на способность к вождению автотранспорта и управлению потенциально опасными механизмами: рекомендуется соблюдать осторожность, так как возможное негативное влияние на способность к вождению автомашины и управлению сложными механизмами не может быть исключено. При появлении побочных эффектов со стороны центральной нервной системы следует воздержаться от управления автотранспортом и работы с потенциально опасными механизмами.

Состав

  • Один суппозиторий содержит: активные вещества: метронидазол 500 мг, миконазола нитрат 100 мг; вспомогательные вещества: полусинтетические глицериды (Суппоцир АМ) - достаточное количество для получения суппозитория массой 2000 мг.

Метромикон-Нео показания к применению

  • Влагалищные инфекции: вагинальный кандидоз; трихомонадный вагинит и вульвовагинит, бактериальный вагиноз; смешанная вагинальная инфекция.

Метромикон-Нео противопоказания

  • Гиперчувствительность к компонентам препарата или другим производным нитроимидазола, беременность, период лактации.

Метромикон-Нео дозировка

  • 500 мг + 100 мг

Метромикон-Нео побочные действия

  • Местные реакции: жжение, зуд, раздражение слизистой оболочки влагалища и усиление отечности. Из-за воспаления слизистой оболочки влагалища при вагините раздражение может усиливаться после введения первого суппозитория или к третьему дню лечения. Эти осложнения быстро исчезают после прекращения лечения. Со стороны желудочно-кишечного тракта: боль или спазмы в животе, «металлический» привкус, сухость во рту, запор, диарея, потеря аппетита, тошнота, рвота. Со стороны нервной системы: головная боль, двигательные нарушения (атаксия), головокружение, психоэмоциональные нарушения, судороги. Со стороны системы кроветворения: лейкопения. Аллергические реакции: кожные высыпания, в том числе крапивница.

Лекарственное взаимодействие

В связи с попаданием метронидазола в системный кровоток могут отмечать следующие реакции взаимодействия при одновременном применении с некоторыми веществами: Пероральные антикоагулянты: усиливается действие непрямых антикоагулянтов. Дисульфирам: могут наблюдаться нарушения со стороны ЦНС (психические реакции); не следует назначать метронидазол больным, которые принимали дисульфирам в течение последних 2 недель; Фенитоин: повышается концентрация фенитоина в крови, а концентрация метронидазола в крови снижается. Препараты лития: может наблюдаться повышение их токсичности. Фенобарбитал: снижается концентрация метронидазола в крови. Циметидин: может повыситься концентрация метронидазола в крови. Астемизол и терфенадин: метронидазол и миконазол ингибируют метаболизм этих препаратов и повышают концентрацию в плазме крови. Этанол: взаимодействие метронидазола с этанолом вызывает дисульфирамоподобные реакции.

Передозировка

При соблюдении рекомендуемых доз, в связи с низкой абсорбцией препарата, случаи передозировки не выявлены. Возможные симптомы: тошнота, рвота, боль в животе, диарея, зуд, металлический привкус во рту, атаксия, головокружение, парестезии, периферическая невропатия (при продолжительном применении в высоких дозах), судороги, лейкопения, темное окрашивание мочи (обусловлено передозировкой метронидазола). Симптомы передозировки миконазола не выявлены. Лечение: симптоматическая и поддерживающая терапия, при случайном приеме внутрь — промывание желудка.

Условия хранения

  • хранить в сухом месте
  • хранить при комнатной температуре 15-25 градусов
  • беречь от детей
  • хранить в защищенном от света месте
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