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Лекарственный препарат Метрогил Плюс

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            [DETAIL_TEXT] => 
            [DETAIL_TEXT_TYPE] => text
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            [IBLOCK_NAME] => Торговые предложения
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            [CANONICAL_PAGE_URL] => 
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                            [USER_TYPE_SETTINGS] => 
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                            [XML_ID] => 
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                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
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                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
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                            [IBLOCK_ID] => 26
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                            [SORT] => 500
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                            [MULTIPLE] => Y
                            [XML_ID] => 
                            [FILE_TYPE] => jpg, gif, bmp, png, jpeg
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
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                            [VALUE_ENUM_ID] => 
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                    [COLOR] => Array
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                            [IBLOCK_ID] => 26
                            [NAME] => Цвет
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                            [SORT] => 500
                            [CODE] => COLOR
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => directory
                            [USER_TYPE_SETTINGS] => Array
                                (
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                                    [width] => 0
                                    [group] => N
                                    [multiple] => N
                                    [TABLE_NAME] => universe_colors
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                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
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                    [SIZE] => Array
                        (
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                            [TIMESTAMP_X] => 2018-06-18 20:19:18
                            [IBLOCK_ID] => 26
                            [NAME] => Размер
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                            [SORT] => 500
                            [CODE] => SIZE
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
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                            [VALUE_ENUM_ID] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
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                        )

                    [STARTSHOP_LINK] => Array
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                            [CODE] => STARTSHOP_LINK
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
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                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
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                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
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                            [IBLOCK_ID] => 26
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                            [SORT] => 500
                            [CODE] => NAME
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                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
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                            [VALUE_XML_ID] => 
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                            [NAME] => URL
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                            [XML_ID] => 
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                            [TMP_ID] => 
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                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
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                            [VALUE_SORT] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => URL
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                            [IBLOCK_ID] => 26
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                            [XML_ID] => 
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                            [XML_ID] => 
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                            [TMP_ID] => 
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                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
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                            [TIMESTAMP_X] => 2019-10-14 16:10:42
                            [IBLOCK_ID] => 26
                            [NAME] => Партнерская ссылка
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                            [SORT] => 500
                            [CODE] => PARTNER_URL
                            [DEFAULT_VALUE] => 
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
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                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
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                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => Партнерская ссылка
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                        (
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                            [TIMESTAMP_X] => 2019-10-14 19:00:11
                            [IBLOCK_ID] => 26
                            [NAME] => ID лекарства в партнерке
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                            [SORT] => 500
                            [CODE] => ID_PARTNER_LEK
                            [DEFAULT_VALUE] => 
                            [PROPERTY_TYPE] => S
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                            [COL_COUNT] => 30
                            [LIST_TYPE] => L
                            [MULTIPLE] => N
                            [XML_ID] => 
                            [FILE_TYPE] => 
                            [MULTIPLE_CNT] => 5
                            [TMP_ID] => 
                            [LINK_IBLOCK_ID] => 0
                            [WITH_DESCRIPTION] => N
                            [SEARCHABLE] => N
                            [FILTRABLE] => N
                            [IS_REQUIRED] => N
                            [VERSION] => 1
                            [USER_TYPE] => 
                            [USER_TYPE_SETTINGS] => 
                            [HINT] => 
                            [PROPERTY_VALUE_ID] => 
                            [VALUE] => 
                            [DESCRIPTION] => 
                            [VALUE_ENUM] => 
                            [VALUE_XML_ID] => 
                            [VALUE_SORT] => 
                            [~VALUE] => 
                            [~DESCRIPTION] => 
                            [~NAME] => ID лекарства в партнерке
                            [~DEFAULT_VALUE] => 
                            [VALUE_ENUM_ID] => 
                        )

                )

            [STARTSHOP] => Array
                (
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                        (
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                                )

                            [MINIMAL] => Array
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                                    [CURRENCY] => RUB
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                                    [TYPE] => BASE
                                )

                        )

                    [BASKET] => Array
                        (
                            [INSIDE] => 
                            [QUANTITY] => 0
                            [PRICE] => Array
                                (
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                                    [CURRENCY] => RUB
                                    [PRINT_VALUE] => 254.90 руб.
                                    [TYPE] => BASE
                                )

                        )

                    [QUANTITY] => Array
                        (
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                            [RATIO] => 1
                            [VALUE] => 100
                        )

                    [AVAILABLE] => 1
                    [OFFER] => Array
                        (
                            [OFFER] => 1
                            [PROPERTIES] => Array
                                (
                                )

                            [LINK] => 10054
                        )

                )

            [PRICE] => Array
                (
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                    [CURRENCY] => RUB
                    [PRINT_VALUE] => 254.90 руб.
                    [TYPE] => BASE
                    [DISCOUNT_VALUE] => 254.90 руб.
                    [PRINT_DISCOUNT_VALUE] => 254.90 руб.
                    [DISCOUNT_DIFF] => 0
                    [DISCOUNT_DIFF_PERCENT] => 0
                )

            [CATALOG_QUANTITY] => 100
            [MAX_QUANTITY] => 100
            [CATALOG_MEASURE_RATIO] => 1
            [MEASURE] => 
            [CAN_BUY] => 1
            [CAN_BUY_ZERO] => 
        )

    [19182] => Array
        (
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            [MODIFIED_BY] => 1
            [DATE_CREATE] => 30.01.2019 19:14:57
            [DATE_CREATE_UNIX] => 1548850497
            [CREATED_BY] => 1
            [IBLOCK_ID] => 26
            [IBLOCK_SECTION_ID] => 
            [ACTIVE] => Y
            [ACTIVE_FROM] => 
            [ACTIVE_TO] => 
            [DATE_ACTIVE_FROM] => 
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Рецептурный препарат Рецептурный препарат. Рецепт остается в аптеке

Инструкция по применению Метрогил Плюс

Производитель

Юник Фармасьютикал Лабораториз(Отделение фирмы Дж.

Страна происхождения

Индия

Группа товаров

Антибактериальные препараты

Противомикробное комбинированное средство (противомикробное и противопротозойное средство+противогрибковое средство)

Формы выпуска

  • гель в тубе 50,0 + 10 апппликаторов в коробке туба 50,0 в инд/уп

Описание лекарственной формы

  • Гель вагинальный белого или почти белого цвета, опалесцирующий, однородный Гель вагинальный белого или почти белого цвета, опалесцирующий, однородный.

Фармакологическое действие

Комбинированный препарат для интравагинального применения, эффективность которого обусловлена наличием в его составе двух компонентов: метронидазола и клотримазола. Метронидазол активен в отношении простейших: Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, а также грамотрицательных анаэробов: Bacteroides fragilis, Fusobacterium spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens), Gardnerella vaginalis и некоторых грамположительных микроорганизмов: Clostridium perffringens, Clostridium difficile, Peptococcus spp., Peptostreptococcus spp. МПК для этих штаммов составляет 0.125-6.25 мкг/мл. Клотримазол оказывает фунгицидное и бактерицидное действие. Тормозит биосинтез эргостерола, регулирующего проницаемость клеточной стенки микроорганизмов. В малых концентрациях действует фунгистатически, а в больших - фунгицидно. В фунгицидных концентрациях взаимодействует с пероксидазами и митохондриальными ферментами, в результате чего происходит увеличение концентрации перекиси водорода до токсического уровня, что также ведет к гибели грибов. Обладает высокой активностью в отношении грибов: Blastomyces dermatitidis, Candida spp., Coccidioides immitis, Cryptococcus neoformans, дерматофитов (Trichophyton mentagrophytes, Microsporum canis, Epidermophyton foccosum), Histoplasma capsulatum, Paracoccidioides brasiliensis, Sporothrix schenckii; простейших: Trichomonas vaginalis; грамположительных бактерий: Streptococcus spp., Staphylococcus spp., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis.

Фармакокинетика

Метронидазол Всасывание После интравагинального введения метронидазол подвергается системной абсорбции (около 56%). Относительная биодоступность метронидазола в форме вагинального геля в 2 раза выше биодоступности метронидазола в форме влагалищных таблеток при однократном применении в дозе 500 мг. После однократного интравагинального введения геля в дозе 5 г (50 мг метронидазола) средняя Cmax в сыворотке крови здоровых женщин равна 237 нг/мл, что составляет 2% от средней Cmax метронидазола при приеме внутрь в дозе 500 мг. Время достижения Cmax — 6-12 ч. Распределение Проникает в большинство тканей, проходит через ГЭБ и плацентарный барьер. Выделяется с грудным молоком. Связывание с белками плазмы составляет менее 20%. Метаболизм и выведение Метаболизируется в печени путем гидроксилирования, окисления и глюкуронирования. Активность основного метаболита (2-оксиметронидазол) составляет 30% активности исходного соединения. Выводится почками 60-80% (20% - в неизмененном виде), через кишечник - 6-15%. Клотримазол При применении клотримазола интравагинально абсорбируется не более 3-10%. Высокие концентрации в вагинальном секрете и низкие концентрации в крови сохраняются в течение 48-72 ч. В печени клотримазол быстро метаболизируется до неактивных метаболитов.

Особые условия

При применении препарата противопоказано употребление алкоголя (возможно развитие дисульфирамоподобной реакции: спастические боли в животе, тошнота, рвота, головная боль, внезапный прилив крови к лицу). Метронидазол может иммобилизовать трепонемы и приводить к ложноположительному тесту Нельсона. Препарат предназначен только для интравагинального применения. Следует избегать попадания препарата в глаза. Во время курса терапии необходимо воздерживаться от половой жизни. Передозировка Случаев передозировки препарата при назначении в рекомендуемых дозах не наблюдалось.

Состав

  • 1 г метронидазол 10 мг клотримазол 20 мг Вспомогательные вещества: метилгидроксибензоат, пропилгидроксибензоат, динатрия эдетат, пропиленгликоль, карбомер-940, бензиловый спирт, натрия гидроксид, вода очищенная.

Метрогил Плюс показания к применению

  • — бактериальные вагинозы различной этиологии, подтвержденные клиническими и микробиологическими данными; — кандидозные вульвиты и вульвовагиниты; — урогенитальный трихомониаз.

Метрогил Плюс побочные действия

  • Местные реакции: ощущение жжения или учащенное мочеиспускание; у полового партнера - ощущение жжения или раздражение полового члена. Системные реакции: возможно головокружение, головная боль, тошнота, спастические боли в брюшной полости. Аллергические реакции: кожная сыпь, крапивница. Пациент должен быть предупрежден о необходимости прекратить применение препарата и обратиться к врачу в случае возникновения любых нежелательных побочных эффектов.

Лекарственное взаимодействие

При одновременном применении препарат усиливает действие непрямых антикоагулянтов. Не рекомендуется совместное применение с недеполяризующими миорелаксантами (векуроний). При одновременном применении с препаратами лития возможно повышение концентрации лития в плазме крови. Фенобарбитал ускоряет метаболизм метронидазола за счет индукции микросомальных ферментов печени, циметидин - снижает Амфотерицин В, нистатин, натамицин снижают эффективность клотримазола при одновременном применении. При одновременном применении с этанолом препарат может вызвать дисульфирамоподобные реакции.

Условия хранения

  • хранить при комнатной температуре 15-25 градусов
  • беречь от детей
Отзывы Метрогил Плюс
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